Analysis of M2 haplotype of ANXA5 gene-diagnosis of recurrent miscarriages

Analysis of the M2 haplotype of the ANXA5 gene-diagnosis of recurrent miscarriages

Clinical significance

Recurrent (recurrent) miscarriages affect approximately 1-2% of women and represent three or more consecutive losses of early pregnancies. Recurrent miscarriages also account for rów 5% of all spontaneous miscarriages and the cause of the loss of 0.4-0.8% of all pregnancies. The most commonly cited causes of miscarriages are genetic, anatomical, immunological, hormonal, and infectious factors. The presence of a characteristic genetic combination (called the M2 haplotype) in the ANXA5 gene is associated with decreased production of blood clotting-lowering factor in the placenta. The risk of pregnancy loss is increased when the M2 haplotype in the ANXA5 gene is present in one of the prospective parentsów. If the developing fetusód inherits the M2 haplotype, the reduced protein will increase the risk of developing clotsóin the placenta, resulting in miscarriage.

Patient Preparation

Material: EDTA blood