Panorama 22q11.2

Dear Patient,

For your convenience and safety, please book an appointment by phone at the Synevo Intake Point of your choice at 22 120 24 00

Panorama prenatal tests

The Panorama test is a non-invasive, safe, screening prenatal test.

The Panorama test allows you to determine the risk of common genetic defects caused by extra or missing chromosomes in the baby's DNA:

1. Down syndrome (trisomy 21)

2. Edwards syndrome (trisomy 18)
3 3. Patau syndrome (trisomy 13)
4. triploidy
5. sex chromosome abnormalities:

• Turner syndrome (monosomy X)
• Klinefelter syndrome (XXY)
• Jacobs syndrome (XYY)
• triple X syndrome (XXX)

Triploidy is a chromosomal abnormality very often leading to fetal demise, associated with severe birth defects and pre-eclampsia. Births are extremely rare.

The Panorama test can determine the risk of 22q11.2 deletion syndrome (DiGeorge associated with serious health problems

The Panorama test can be performed after the end of 9 weeks of pregnancy, up to the day of delivery.

Before performing the Panorama test, it is necessary to perform an ultrasound focused on assessing the number of fetuses and gestational age, so it is most optimal to perform the Panorama test after the first prenatal ultrasound 11-14 weeks.

The Panorama test is not a substitute for first trimester pregnancy screening, including ultrasound, which should be performed according to the recommendations of the Polish Gynecological Society.

In a small percentage of cases, the Panorama test may not be able to obtain enough information from the blood sample to determine an accurate result. If this is the case, a second blood sample may need to be taken. This happens more often with pregnancies in patients with obesity.

The Panorama test is intended for pregnant women, regardless of age, except in the case of:

• multiple pregnancies of more than 2 fetuses,
• death of one of the twins,
• twins conceived with the help of a surrogate or egg donor,
• pregnancy after a bone marrow transplant,
• less than 6 months after blood transfusion,
• before the end of 9 weeks of pregnancy,

You may want to consider taking the Panorama test after consulting with your pregnancy doctor to make an informed decision.

Is a Panorama test the same as a Pappa test?

No. The Panorama test examines the fractions of fetal DNA present in the mother's blood, while the Pappa test is based on an assessment of PAPP-A protein levels, the free β-hCG subunit and the nuchal translucency image seen on ultrasound. The Panorama test can be the next step in fetal diagnosis when the risk on the Pappa test is between 1:100 and 1:1000.

How to run the test?

1. Patient purchases the test online
2. Patient downloads and fills out the referral and consent declaration (available under “documents”). We highly recommend filling out the referral together if the OB-GYN managing pregnancy
3. Patient report to Blood Draw Point with all the above mentioned documents (recommended time is Monday-Thursday 8-11 am)
4. A trained nurse controls the documents and hands out an information leaflet about Panorama Test (also available under “Documents”
5. After a positive verification of the documents, blood sample is taken from patient’s arm
6. After up to 14 days patient receives telephone call informing her that the results are ready to be picked up at the reception desk.

You must have a valid ID on you when reporting for the blood draw!

We highly recommend discussing the results with trained OB-GYN Physician

Every patient must report to the blood draw point with all necessary documents! If you have problem filling them out, please see “Sample Referral” under “Documents” tab

Additional Information

The test is not a diagnostic examination, which means that it does not detect genetic diseases of the child, but does however estimate the risk rate of them occurring. The exam is based on a DNA analysis of the embryo, which is currently in the mother’s circulation system. The sample is taken to a laboratory where it is tested for genetic changes that could later impact the child’s health.

Panorama test is supplementary to regular screening tests performed in the first trimester of pregnancy, including USG, which should be run according to the current guidelines of The Polish Society Of Gynecologists and Obstetricians

You can consult advantages of Panorama Test after consultation with your OB-GYN Physician to make a conscious decision.