CD4/CD25 regulatory T-cell subpopulation

Subpopulation of CD4/CD25 regulatory T lymphocytes

Clinical significance

CD4+ CD25+ regulatory T lymphocytes are cells thatóre inhibit the proliferation of effector lymphocytes, as well as their secretion of pro-inflammatory cytokines. Regulatory T lymphocytes can also rów induce suppressor T lymphocytes, through which they affect all cellsór of the immune system. Thus, CD4+ CD25+ regulatory T lymphocytes are responsible for controlling and inhibiting excessive immune responses, especially against their own antigensów. The distribution of own and foreign antigens by immunocompetent cells enables the immune system to respond effectively against pathogensów and prevents the development of autoimmune processes. Regulatory T lymphocytes are involved in, among other things: the generation of tolerance to antigens, in the anti-infective, anti-tumor, immune response after immunization, the course of pregnancy, the formation of tolerance to transplanted organsów, inhibit autoreactive lymphocytes. Overreactivity of regulatory T cells causes silencing of the immune response. which can lead to the development of cancerous phenomena or insufficient removal of infectious agents that cause inflammation. Deficiencyór or dysfunction of these cells can cause autoimmune diseases.

Patient Preparation

Material: heparinized blood