Soluble fms-like tyrosine kinase-1 (sFlt-1)

Soluble fms

The determination of soluble fms-like tyrosine kinase 1 (sFlt-1) is used in the diagnosis of pre-eclampsia Pre-eclampsia in pregnant women. Pre-eclampsia is characterized by the presence of hypertension (caused by pregnancy) and excretion of protein in the urine. It threatens the the health and life of both the woman and the unborn child SFlt-1 is a soluble receptor for growth factor vascular endothelial growth factor (VEGF) secreted by the embryo. In pregnancy physiological pregnancy, sFlt-1 determines the normal development of the placenta However, in women at risk of pre-eclampsia, from the second trimester, the concentration of sFlt-1 begins to increase. this increase occurs still in the early stage of the disease, which is asymptomatic. Testing sFlt-1 (together with the determination of PLGF, the lachrymal growth factor) allows early detection of the disease risk and implementation of appropriate preventive measures appropriate preventive measures.