SARS-CoV-2 virus IgG antibodies quantitative

Antibodies to the SARS-CoV-2 coronavirus after the vaccination

COVID-19 is a disease that can present in the form of respiratory failure, as well as multi-organ failure with severe course. The agent responsible for causing it is the virus SARS-CoV-2 of the coronavirus family. SARS-CoV-2 infection can have an also asymptomatic or mild form.

The diagnostic test that is recommended to be performed after the SARS-CoV-2 vaccination is a serological test, which consists of quantitative evaluation in venous blood of the concentration of specific antibodies directed against the virus. This test allows evaluate the immune response after vaccination consisting of production of specific antibodies against SARS-CoV-2.

Testing of antibodies against SARS-CoV-2 coronavirus after Vaccination - when should it be done?

Vaccination is designed to produce immunity by the immune system directed against a particular pathogen.

This ensures that in vaccinated individuals, the next time they come into contact with a pathogen, defense mechanisms are triggered, which ultimately course.

The vaccination results in the production of specific antibodies in the class of IgG directed against the RBD receptor domain, which is located located on the SARS-CoV-2 virus spike protein S. This fragment of the virus is responsible for the ability of the coronavirus to enter the cells of the of the host, where it multiplies and consequently to pass through and infect neighboring cells and tissues.

In order to determine the effectiveness of the vaccine in a given individual, IgG antibodies directed against RBD are determined. This type of antibodies is called virus neutralizing antibodies virus, which play an important role in the mechanisms of immunity against COVID-19 disease.

The test is recommended no earlier than 7-15 days after the receiving the second dose of the vaccine . The highest concentration in individuals vaccinated with the second dose of IgG antibodies reach after 4-6 weeks. This is the best time to perform the test. As time, the concentration of antibodies may decrease.

Testing of antibodies to SARS-CoV-2 coronavirus after vaccination - who should perform it?

Quantitative determination of antibodies to SARS-CoV-2 is recommended is mainly for assessing post-vaccination immune response, monitoring antibody levels, and in patients after overtreatment (IgG antibodies are formed both after overdiagnosis as well as after vaccination.

Testing of antibody concentrations against SARS-CoV-2 coronavirus after vaccination - interpretation of results

The measurement range for the IgG antibody assay is 2.98-5600 BAU/ml. The results of very high concentrations of antibodies, i.e is more than 5600 BAU/ml, will be presented as >5600 BAU/ml.

A positive result of this test means that the immune system immune system has produced specific antibodies in amounts that effectively should protect a person from contracting the disease from COVID-19.

The detection of antibodies means that the immune system has produced specific immune antibodies that can protect against contracting COVID-19 or its severe course.

The detection of antibodies means that the immune system has produced specific immune antibodies that can protect against COVID-19 or its severe course.

The absence of antibodies does not preclude the acquisition of immunity to the infection of SARS-CoV-2. Its confirmation, however, requires the performance of specialized tests to assess cellular immunity. It may happen, however, that the immune system reacts abnormally to both the vaccine and contact with this pathogen. The result of this may result in a lack of immunity to the disease

The waiting time for the test result is up to 2 working days working days.

Important

Post-vaccination antibodies are directed only against the S protein of the virus. As a result of being overvaccinated, there may be antibodies to the S protein and/or antibodies to the protein of the Nucleocapsid N.

Not all test subjects produce antibodies following vaccination. This is a highly individual personal characteristic Antibodies may be formed at different times, in different concentrations or they may be absent.

Do not compare the concentration of antibodies determined by different methods, even if the result is reported in the same units of BAU/ml. If you want to assess the dynamics of changes in antibody concentration over time then the test should be performed with the same test and in the same laboratory.