IgA and IgG Antibodies Against Neuronal Transglutaminase 6

What is neuronal transglutaminase 6 and why is it important?

Neuronal transglutaminase 6 (TG6) is an enzyme present in the nervous system that may become the target of an abnormal immune response in individuals with gluten intolerance. In some patients, gluten triggers the production of antibodies not only against tissue transglutaminase 2 (commonly associated with celiac disease) but also against TG6. The presence of these antibodies is linked to neurological symptoms such as gluten ataxia, neuropathy, or balance disorders.

Detecting IgA and IgG antibodies against TG6 allows physicians to better understand the causes of a patient’s symptoms and select an appropriate diagnostic and therapeutic strategy, including dietary recommendations.

When should you consider taking the TG6 antibodies test?

The IgA and IgG anti-TG6 antibody test is particularly recommended in the following cases:

• suspected atypical celiac disease or celiac disease with predominantly neurological symptoms,
• presence of balance and coordination problems (gluten ataxia),
• recurrent or chronic neuropathies of unclear origin,
• difficulty concentrating, chronic fatigue, or unexplained headaches,
• a family history of autoimmune diseases, especially gluten-related disorders,
• monitoring of celiac disease patients who continue to have neurological symptoms despite following a gluten-free diet.

This test is an important supplement to standard celiac disease diagnostics and immunological tests, especially when the clinical picture is atypical.

How is the laboratory analysis performed?

The test measures the presence of two classes of antibodies – IgA and IgG – produced by the immune system in response to gluten and its interaction with neuronal transglutaminase 6. In practice, the laboratory checks whether the patient’s immune system is generating specific antibodies against TG6, which may indicate gluten-related neurological disorders.

The test material is venous blood, collected in a standard way at a blood collection point. The analysis is carried out using modern immunological techniques characterized by high sensitivity and specificity.

How to prepare for the test?

There are no special preparations required before testing for IgA and IgG antibodies against neuronal transglutaminase 6. However, it is recommended to:

• remain on a gluten-containing diet – eliminating gluten before the test may reduce antibody levels and lead to false-negative results,
• inform your doctor about any medications or supplements that may affect the immune system,
• follow standard recommendations for blood collection – ideally, the test should be performed on an empty stomach, although this is not strictly required.

The results must always be interpreted in the context of the patient’s clinical picture, other immunological tests, and, if applicable, histopathological examinations.

Clinical significance and interpretation

The presence of TG6 antibodies may confirm gluten-related neurological disorders, even if the patient does not present with typical gastrointestinal symptoms. High antibody levels are associated with an increased risk of neurological damage and may justify the implementation of a strict gluten-free diet.

A negative test result does not completely rule out celiac disease or other autoimmune disorders – therefore, results should always be assessed in conjunction with other medical data.

Why choose Synevo for this test?

By choosing Synevo laboratories, patients gain confidence that:

• the test will be performed using modern, reliable diagnostic methods,
• sample collection and analysis follow strict quality standards,
• results will be made available quickly and securely, with online access,
• Synevo offers a wide range of immunological and autoimmune tests, ensuring comprehensive diagnostics,
• professional staff provide guidance and clear information throughout the process.

Thanks to this, the IgA and IgG anti-TG6 antibody test performed at Synevo is an essential step towards understanding and effectively managing gluten-related disorders and neurological autoimmune conditions.