Cytokine polymorphisms (IL1a, IL1b, IL1RA, a-TNF)

Polymorphism of cytokines (IL1a, IL1b, IL1RA, a-TNF)

Clinical significance

Interleukins are proteins thatóre produced in response to inflammation. They regulate all processes thatóre helpful in fighting infection and healing. The production of interleukins, like other proteins in the body, is regulated by DNA. Changes in the genetic material (such as polymorphisms) are responsible for impaired production of interleukins or the production of inactive molecules of these proteins. A gene polymorphism is the simultaneous occurrence in the population of róy allelic forms of a given gene. Interleukin 1 (IL-1) belongs to pro-inflammatory cytokines, while its receptor antagonist (IL-1RN) belongs to anti-inflammatory cytokines thatóre involved in reducing the immune and inflammatory response. The geneów complex encoding IL-1 consists of the IL-1A, IL-1B and IL-1 receptor antagonist (IL--1RN) genes located on the long arm of chromosome 2. IL-1RN is an endogenous inhibitor that competitively blocks the binding of IL--1 to its receptor on target cells. Tumor necrosis factor (a - TNF) has an important metabolic function. It is synthesized by adipose and muscle tissue cells. Polymorphisms of genesów for the tested cytokines are important in many diseases, e.g. allergies, asthma, diabetes.

Patient Preparation

Material: EDTA blood