Anti-tissue transglutaminase IgA antibodies

Determination of igA antibody levels against tissue transglutaminase.

The test is performed to diagnose celiac disease (this visceral disease with a genetic basis characterized by Intolerance to gluten - a protein contained in wheat, rye, barley and contaminated oats).


In celiac disease, gluten has a toxic effect causing villous atrophy intestinal villi.

The presence of IgA antibodies almost unequivocally confirms the disease. In the absence of IgA antibodies with concomitant symptoms suggestive of celiac disease (abdominal pain and bloating, diarrhea fatty or watery diarrhea, weight loss, developmental abnormalities in children, short stature, change in disposition, depression, deficiencies) further diagnosis is necessary.