Anti-platelet antibodies (direct IFT method)

Antiplatelet antibodies, by attaching to the the surface of platelets, enhance their destruction in the spleen, causing thrombocytopenia. Platelet production is insufficient to offset their excessive loss. Symptoms of the disease include: easy bruising, petechiae (especially on the lower extremities, but can occur all over the body). U Some patients are asymptomatic, with bleeding only appearing when the platelet count drops only appear when the platelet count drops below 30,000 Determination of antiplatelet antibodies is characterized by low sensitivity and specificity and is not standardly recommended for the diagnosis of thrombocytopenia diagnosis of thrombocytopenia, but can be helpful in establishing a diagnosis in cases of complex clinical presentation, refractory patients to treatment and drug-dependent spontaneous thrombocytopenia, such as heparin.