Anti-neuronal antibodies by blot method

Antineuronal antibodies are antibodies that attack and destroy the nervous system. Determination of onconeuronal antibodies makes it possible, with the right clinical picture, to diagnose the neurological paraneoplastic syndrome and to take diagnostic measures aimed at determining the location of the primary tumor and implement specific treatment. Each of the antibodies is specific for a given paraneoplastic syndrome and cancer. Anti-Ri: cerebellar ataxia, opsoclonus/myoclonus, cancer of the ovarian, breast, small cell lung cancer; anti - Yo: subacute cerebellar ataxia, ovarian, breast, uterine cancer; anti - Hu: sensory neuropathy, chronic pseudobulbar palsy gastrointestinal tract, encephalomyelitis, limbic system inflammation, cancer of the small cell lung cancer, neuroblastoma; anti - Ma2/Ta: inflammation of the limbic system, testicular tumors; anti - CV2: cerebellar ataxia, sensorimotor neuropathy, choroiditis, retinopathy, encephalomyelitis, small-cell lung cancer, thymoma; anti - amphiphysin: stiff man syndrome, sensory neuropathy, encephalomyelitis, breast cancer, small cell lung cancer.