Methotrexate - a folic acid antagonist, a drug
Anticancer and immunosuppressant. Mechanism of action
involves inhibition of the synthesis of purine nucleotides and thymidines,
which are essential for DNA synthesis and repair and cellular replication
cell replication.The indication for the use of methotrexate is acute
lymphoblastic leukemia in children, acute lymphoblastic and
myeloid leukemia in adults, cancer of the breast, ovary, testes, head, bone and
many others. Testing the serum concentration of this drug is performed
during treatment monitoring. A folic acid analogue - folinate
calcium is a substance administered to a patient who has been
exceeded the recommended concentration of methotrexate.
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