LDH isoenzymes

Lactate dehydrogenase belongs to the group of indicator enzymes Based on changes in the activity of these enzymes in blood serum, it is possible to infer the degree of cellular damage. It is a cytoplasmic enzyme cytoplasmic enzyme commonly found in the tissues of the body The highest LDH activities were found in kidney, liver, heart, skeletal muscle, brain, pancreas, lung, as well as in red blood cells red blood cells, leukocytes and thrombocytes. Lactate dehydrogenase is a tetramer composed of subunits H and M. The enzyme exists in five isoforms: LDH1 and LDH2 (heart muscle, kidney, erythrocytes), LDH3 (lung, pancreas, platelets, lymphoid tissue, tumors), LDH4 and LDH5 (liver, skeletal muscle, tumors). Rarely, there may two more isoenzymes appear - LDH-X (LDH-C) detected in healthy adults, and LDH6 in terminal diseases.