Diagnostics of genetic predisposition to psoriasis - HLA-Cw6

Clinical significance:

Detection of HLA-Cw6 allele - diagnosis of susceptibility to psoriasis - a chronic inflammatory disease with characteristic skinr changes.

Required to complete the Order and Declaration of Informed Consent for genetic testing.
Identification of the HLA-Cw6 gene is useful in the rs differentiation of psoriasis forms, in separating psoriasis from other autoimmune conditions, and in predicting response to biologic therapy. Psoriasis is a chronic and relapsing disorder of the skinry and jointsw of a hereditary nature, affecting about 2% of the Polish population. The presence of psoriasis in one parents family implies a 25% risk of the child developing psoriasis.

The risk of psoriasis in a child of both parentsof psoriasis patients rises to 70%.  The risk of psoriasis in a sibling of a child with psoriasis is 20%.  The primary genetic factor associated with psoriasis is the HLA*06 gene located on chromosome 6, whichry encodes the HLA-Cw6 antigen. The presence of this gene is a criterion for the division of psoriasis into psoriasis vulgaris type I (gene in 80% of patients) or II (gene rather absent - in 15% of patients). In patients who have HLA*06, the disease appears earlier, i.e. before the age of 30, and is more aggressive.

Identification of the HLA-Cw6 gene is useful in the rdifferentiation of psoriasis forms and in the rdifferentiation of psoriatic arthritisfrom rheumatoid arthritisw (RA), ankylosing spondylitisspine (AS) and osteoarthritisw. The presence of the HLA-Cw6 gene is an indicative marker of a stronger response to biologic therapy.

A HLA*06 positive result indicates a genetic predisposition to psoriasis; HLA*06 negative indicates no genetic predisposition.