Adenosine deaminase

Adenosine deaminase ADA - an enzyme that determines the conversion of adenosine to inosine and deoxyadenosine to deoxyinosine. ADA occurs in the form of form of two isoenzymes ADA1 - in lymphocytes, macrophages neutrophils, ADA2 - in monocytes and macrophages. ADA deficiency results in accumulation of deoxyadenosine triphosphate and inhibition of DNA synthesis. As a consequence, immune deficiencies occur.