CYFRA 21-1 (non-small cell lung cancer, marker of degenerative processes)

CYFRA 21-1 is a polypeptide, a soluble fragment of the cytokeratin 19 with a molecular weight of 30 kDa.
Expression of this marker has been demonstrated in squamous monolayer epithelium (gallbladder, glandular ducts of pancreas and salivary glands, intestinal and gastric mucosa) and pseudolayered nonproliferative (lungs, urinary bladder).
The main indication for the assay is to monitor the course of treatment of non-small cell lung cancer, especially squamous cell carcinoma (sensitivity of 80%).
Elevated levels of this marker are found in 50-70% of patients The percentage of elevated results increases with the stage of disease.
The concentration of the marker also shows a clear correlation with tumor mass, the status of the lymph nodes and the presence of distant metastases. An increase in concentrations are also observed in other cancers squamous cell carcinomas (esophageal cancer, breast cancer, cervical cancer uterus).
In non-cancerous diseases, elevated concentrations are found in patients with non-malignant lung diseases (pneumonia, sarcoidosis, tuberculosis, chronic bronchitis, bronchial asthma, emphysema), liver diseases (inflammation, cirrhosis), diseases of the kidneys.