IMPORTANT!
In order to perform the PAPP-A test, it is necessary to purchase the tests at once 2 tests in one order:
Determination of plasma pregnancy protein in the blood of pregnant women used together with the determination of free ß-hCG unit as a screening test for the detection of the following chromosomal aberrations: Down syndrome, Edwards syndrome and Patau syndrome.
Pregnancy protein A is a glycoprotein, a metalloproteinase secreted by the syncytiotrophoblast. The concentration of PAPPA-A in the blood of a pregnant woman increases from the 6th week of pregnancy until delivery.
This protein can also be produced by fibroblasts, smooth muscle cellsrs and osteoblasts. The main action of PAPPA-A is immunosuppression, regulating the delivery of nutrients to the fetus. Determination of the free subunit of ß-hCG is, in addition to determination of pregnancy protein A, the recommended biochemical test for pregnant women by the Polish Gynecological Society and FMF (Fetal Medicine Foundation in London), performed between 11 and 13 weeks of pregnancy.
The PAPP-A test (determination of PAPPA-A and the free subunit of ß-HCG) addresses three chromosomal aberrations: Down syndrome, Edwards syndrome and Patau syndrome.
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