BDNF - brain-derived neurotrophic factor

Clinical significance:

Brain-derived neurotrophic factor (BDNF) belongs to a group of secretory polypeptidess, so-called neutrophins. Together with other proteins, it is involved in the function of neuronsw and influences the function of the central and peripheral nervous systems.

The BDNF factor is localized (against the nervous system) also in the heart, skeletal muscles, smooth muscle cells, lungs, blood pythons and fibroblasts. Contributes to the development of stem cellsre. Influences regenerative processes of nerve cellsre following: ischemic stroke, post-traumatic condition, toxic poisoning.

The concentration of BDNF measured in the hippocampus – the structure of the mzygus responsible for memory – increases with increased exercise time. In contrast, a decrease in neurotrophin levels through exposure to stress, depressive states, or in the elderly leads to a deterioration in the ability to remember assigned tasks.

Deficiency of BDNF is associated with diseases such as depression, schizophrenia, autism, obesity, Alzheimer's disease, Parkinson's disease.