Arylsulfatase

ARSO is an enzyme that catalyzes the breakdown of sulfuric acid esters Its high content is found in liver tissue, pancreas and kidneys. ARSA arylsulfatase deficiency is the cause of leukodystrophy metachromatic (MLD), a genetically determined disease that results in the which results in the accumulation of sulfatide deposits in the nervous system and internal organs. This causes changes in brain and nervous tissue. Elevated levels of the enzyme is found in cancer tissue of the stomach, colon, breast and bladder urinary bladder. There is a correlation between the activity of the enzyme and the incidence of metastasis.