Analysis of the CDKN2A gene full coding sequence - diagnostics of hereditary melanoma and pancreatic cancer syndrome

Malignant melanoma is one of the most malignant cancersów, occurring in Poland at a rate of close to 2,000 casesów per year, with a clear upward trend. Up to 15% of melanoma cases are familial. The cause of the disease is the loss of function of the suppressor protein P16, and a second somatic mutation enables the developmentóy of a tumor that originates in melanocytesóry skin. Hereditary malignant melanoma in about 25-40% of casesóare caused by mutations in the CDKN2A gene on chromosome 9p21.