Analysis of exons 10 and 11 of the RET gene - first stage of diagnostics of medullary thyroid cancer

Familial medullary thyroid cancer is a rare cancer predisposition syndrome, accounting for about 5-10% of thyroid cancersós. The hereditary form occurs in 25-30% of casesów. The cause of the disease is the activation of a protooncogene, leading to neoplastic transformation of the perivascular C-cells of the thyroid. Approximately 90% of the casesóve disease are caused by mutation of the RET gene on chromosome 10q11.