Analysis of exons 10, 11, 15 and 16 of the RET gene - diagnostics of multiple endocrine adenomatosis type 2A and 2B (MEN2A and MEN2B)

Multiple endocrine adenomatosis type 2 is a rare cancer predisposition syndrome, with an estimated incidence of 1:35,000. The disease is caused by activation of a protooncogene, which leads to the development of cancersów of glands of the endocrine system, especially the thyroid, adrenal and parathyroid glands. The disease is caused by a mutation of the RET gene on chromosome 10q11.2. Specific mutations are observed, located mainly in the middle and terminal regions of the gene.